Exploratory Analysis Identifies Biomarkers of Response in TNBC

Source link : https://www.newshealth.biz/health-news/exploratory-analysis-identifies-biomarkers-of-response-in-tnbc/ New biomarker analyses from the phase 3 KEYNOTE-522 trial provide insights into the biological factors that may influence response to pembrolizumab plus chemotherapy in early-stage triple-negative breast cancer (TNBC). The new research, presented by Joyce O’Shaughnessy, MD, at San Antonio Breast Cancer Symposium (SABCS) 2024, also reinforces the broad benefit of […]

When to Use Anthracyclines in Early Breast Cancer

Source link : https://www.newshealth.biz/health-news/when-to-use-anthracyclines-in-early-breast-cancer/ SAN ANTONIO — Patients with early-stage, node-negative, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer and a high risk for recurrence benefited more from adding adjuvant anthracyclines to taxane-based chemotherapy than from taxane-based chemotherapy alone, according to a post-hoc analysis of the TAILORx study. More specifically, patients […]

Would Healing Toolbox Requires Frequent Updating

Source link : https://www.newshealth.biz/health-news/would-healing-toolbox-requires-frequent-updating/ NEW YORK — Instructions on wound healing often involve disturbing photographs of severe diabetic ulcers, angry autoimmune blistering, and oozing lesions produced by uncommon genetic disorders, but day-to-day dermatologic care of wounds, whether they are dramatic, relies on both the basics and novel approaches, according to a well-known wound treatment expert. […]

ARN Inhibitor Reduces Major CV Events in AMI

Source link : https://www.newshealth.biz/health-news/arn-inhibitor-reduces-major-cv-events-in-ami/ TOPLINE: In patients with heart failure (HF) due to acute myocardial infarction (AMI), angiotensin receptor–neprilysin (ARN) inhibitors lower the risk for cardiovascular (CV) events, reduce HF rehospitalizations, and improve cardiac remodeling. METHODOLOGY: A meta-analysis of nine studies (eight randomized controlled trials and one echo substudy) conducted until February 2024 included 6597 […]

One in four babies born by Caesarean in England

Source link : https://www.newshealth.biz/health-news/one-in-four-babies-born-by-caesarean-in-england/ Getty Images One out of every four babies is now born by Caesarean section, latest NHS data for England reveals. The proportion has increased steadily over the past decade. Experts say it is linked to a “growing number” of more “complex” pregnancies – because the mother is older or obese, for […]

Better HRQOL With Radiotherapy for 70+ with Early Breast Cancer

Source link : https://www.newshealth.biz/health-news/better-hrqol-with-radiotherapy-for-70-with-early-breast-cancer/ SAN ANTONIO — Women 70 years or older with early luminal A-like breast cancer who received postoperative radiotherapy alone following surgery reported having better health-related quality of life at 24 months of follow-up than their peers who received only adjuvant endocrine therapy. These findings come from a planned interim analysis of […]

CAR-T Cells and Beyond: Breakthroughs and Challenges Ahead

Source link : https://www.newshealth.biz/health-news/car-t-cells-and-beyond-breakthroughs-and-challenges-ahead/ Chimeric antigen receptor (CAR)-T cells and T-cell therapies have been used in the treatment of various cancers for several years. In a review published in JAMA, a research team led by Christian Hinrichs, MD, of the Rutgers Cancer Institute of New Brunswick, New Jersey, summarizes the current understanding of cellular immunotherapies […]

ARN Inhibitor Reduces Major CV Events in AMI

Source link : https://www.newshealth.biz/health-news/arn-inhibitor-reduces-major-cv-events-in-ami/ TOPLINE: In patients with heart failure (HF) due to acute myocardial infarction (AMI), angiotensin receptor–neprilysin (ARN) inhibitors lower the risk for cardiovascular (CV) events, reduce HF rehospitalizations, and improve cardiac remodeling. METHODOLOGY: A meta-analysis of nine studies (eight randomized controlled trials and one echo substudy) conducted until February 2024 included 6597 […]

Zebrafish Provide the Keys to the Heart’s ‘Mini-Brain’

Source link : https://www.newshealth.biz/health-news/zebrafish-provide-the-keys-to-the-hearts-mini-brain/ The heart’s “mini-brain” is independent and highly localized, according to researchers at the Karolinska Institutet in Stockholm, Sweden. The findings could lead to new research into arrhythmia, dementia, and Parkinson’s disease. Although controlled by the brain, the heart has a separate, smaller intracardiac nervous system (IcNS) embedded within the superficial layers […]

Biopsy-Free Melanoma Screening Advances

Source link : https://www.newshealth.biz/health-news/biopsy-free-melanoma-screening-advances/ NEW YORK — The total body skin examination with or without dermatoscopy might eventually be marginalized by noninvasive technologies that greatly reduce the need for biopsy while increasing sensitivity and specificity, according to an expert describing four such technologies now in routine use at his own institution. For skin cancer screening, […]

Big Prevention Benefits With Daratumumab?

Source link : https://www.newshealth.biz/health-news/big-prevention-benefits-with-daratumumab/ SAN DIEGO — The multiple myeloma (MM) drug daratumumab (Darzalex), an anti-CD38 monoclonal antibody, dramatically reduced progression to active MM or death in patients with high-risk smoldering MM (SMM), a landmark randomized, open-label, phase 3 study found. Among 390 patients with SMM (194 assigned to daratumumab and 196 to active monitoring), […]

DCIS QOL Outcomes Similar With Active Monitoring Vs Surgery

Source link : https://www.newshealth.biz/health-news/dcis-qol-outcomes-similar-with-active-monitoring-vs-surgery/ TOPLINE: Women with low-risk ductal carcinoma in situ (DCIS) who underwent active monitoring showed similar quality of life (QOL), anxiety levels, and symptom trajectories compared with those receiving surgery during 2 years of follow-up. The study included 957 participants with a completion rate exceeding 83% at all assessment points. METHODOLOGY: Prior […]

Carfentanil-Involved Drug Overdoses Soar From 2023 to 2024

Source link : https://www.newshealth.biz/health-news/carfentanil-involved-drug-overdoses-soar-from-2023-to-2024/ The number of drug overdose deaths involving illegally manufactured fentanyl and fentanyl analogs (IMFs) dropped in the United States during the latter portion of 2023. But a new report from the Centers for Disease Control and Prevention (CDC) suggests that an increase in overdoses involving the potent fentanyl analog carfentanil threatens […]

‘New Hope’ for Alcohol Use Disorder Treatment

Source link : https://www.newshealth.biz/health-news/new-hope-for-alcohol-use-disorder-treatment/ Evidence is mounting that new therapies already used to treat gut diseases, type 2 diabetes, and obesity may help people with alcohol use disorder (AUD). Glucagon-like peptide 1 (GLP-1) receptor agonists, first used to treat diabetes and now widely used for weight loss, and fecal microbiota transplants (FMTs), used to treat […]

Palbociclib Combo Tops Chemo in High-Risk Breast Cancer

Source link : https://www.newshealth.biz/health-news/palbociclib-combo-tops-chemo-in-high-risk-breast-cancer/ The phase III PADMA trial demonstrated that first-line treatment with palbociclib plus endocrine therapy (ET) significantly improves outcomes compared with standard mono chemotherapy in patients with high-risk hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2−) metastatic breast cancer. The findings, presented at San Antonio Breast Cancer Symposium […]

Easy Access to Conventional FMT Continues — for Now

Source link : https://www.newshealth.biz/health-news/easy-access-to-conventional-fmt-continues-for-now/ Although the US Food and Drug Administration (FDA) has approved two microbial therapies to prevent recurrent Clostridioides difficile infection (CDI), the preferred treatment of conventional fecal microbiota transplantation (FMT) for severely affected patients may no longer be readily available. An FDA guidance issued in November 2022 limiting stool banks from providing donor […]

Novel Telecare Approach Transforms Care for Alcohol Use

Source link : https://www.newshealth.biz/health-news/novel-telecare-approach-transforms-care-for-alcohol-use/ TOPLINE: A new telephone-based program implemented in a Federally Qualified Health Center (FQHC) demonstrates effectiveness in reducing unhealthy alcohol use among diverse adult patients screened using the Alcohol Use Disorders Identification Test (AUDIT). METHODOLOGY: Researchers implemented a screening and team-based telephonic program within a large FQHC system in Texas in which […]

Epilepsy Tied to Higher Risk for Psychiatric Comorbidities

Source link : https://www.newshealth.biz/health-news/epilepsy-tied-to-higher-risk-for-psychiatric-comorbidities/ TOPLINE: Prevalence of more than a dozen psychiatric disorders — including anxiety and depression — is significantly higher in individuals with epilepsy than in those without, a new meta-analysis suggests.  METHODOLOGY: Researchers conducted a systematic review and meta-analysis of 27 studies They compared the prevalence of 20 common psychiatric disorders between […]

Does Intensive Follow-Up Testing Improve Survival in CRC?

Source link : https://www.newshealth.biz/health-news/does-intensive-follow-up-testing-improve-survival-in-crc/ TOPLINE: In patients with stage II or III colorectal cancer (CRC), frequent follow-up testing with CT scans and serum carcinoembryonic antigen (CEA) screening provides no significant overall or cancer-specific survival benefits at 10 years, according to findings from a secondary analysis. METHODOLOGY: After curative surgery for CRC, intensive patient follow-up is […]

Novel Digital Intervention Shows Promise for Depression

Source link : https://www.newshealth.biz/health-news/novel-digital-intervention-shows-promise-for-depression/ TOPLINE: InterRhythmic care (IRC), a novel digital intervention, was linked to greater improvements in depressive symptoms, anxiety, interpersonal relationships, and social functioning in patients with major depressive disorder (MDD) compared with internet general psychoeducation in new research. METHODOLOGY: The randomized, single-blind trial included 120 outpatients from the Shanghai Mental Health Center […]

A Setback for TNBC Monitoring With Circulating Tumor DNA in ZEST Trial

Source link : https://www.newshealth.biz/health-news/a-setback-for-tnbc-monitoring-with-circulating-tumor-dna-in-zest-trial/ SAN ANTONIO — A first-in-kind trial of molecular residual disease (MRD)-guided therapy in breast cancer came to an early end because of low randomization, but insights can still be gained on the potential use for circulating tumor DNA (ctDNA) to predict disease recurrence. The objective of the ZEST trial was to […]

Mixed Signals From Trials of Perioperative, Neoadjuvant Immunotherapy for Early TNBC

Source link : https://www.newshealth.biz/health-news/mixed-signals-from-trials-of-perioperative-neoadjuvant-immunotherapy-for-early-tnbc/ SAN ANTONIO — Two trials of neoadjuvant immunotherapy for triple-negative breast cancer (TNBC) produced mixed efficacy signals. The NSABP B-59/GBG-96-GeparDouze trial showed that adding perioperative atezolizumab (Tecentriq) to neoadjuvant chemotherapy failed to improve event-free survival (EFS) despite a significant improvement in pathologic complete response (pCR). The China-based CamRelief trial also showed […]

‘We’re Putting Teflon in Our Mouth’: What We Heard This Week

Source link : https://www.newshealth.biz/health-news/were-putting-teflon-in-our-mouth-what-we-heard-this-week/ “We’re putting Teflon in our mouth.” — Laurel Schaider, PhD, senior scientist at Silent Spring Institute in Newton, Massachusetts, discussing dental floss as an example of per- and polyfluoroalkyl substances (PFAS) in everyday products. “The least you could do is let people know that there may be heavy metals in products […]

Integrative Dermatology Addresses Unmet Need

Source link : https://www.newshealth.biz/health-news/integrative-dermatology-addresses-unmet-need/ NEW YORK, NY — Integrative care, a combination of conventional and complementary therapies, should not be marginalized if the goal is patient satisfaction, according to a dermatologist who offers alternative therapies as substitutes or adjuncts for patients with skin diseases.  Clinicians antagonistic to integrative care are overlooking conventional evidence of benefit, […]

Nemolizumab Gets FDA Nod for Atopic Dermatitis

Source link : https://www.newshealth.biz/health-news/nemolizumab-gets-fda-nod-for-atopic-dermatitis/ The US Food and Drug Administration (FDA) has approved nemolizumab for moderate-to-severe atopic dermatitis inadequately controlled with topical therapies in patients aged 12 years and older, according to a press release from the manufacturer, Galderma.  Nemolizumab (Nemluvio), a monoclonal antibody administered subcutaneously, targets the interleukin-31 (IL-31) receptor. IL-31 is known to […]

A Psychiatrist’s Prescription for Americans’ Anger

Source link : https://www.newshealth.biz/health-news/a-psychiatrists-prescription-for-americans-anger/ Lazarus is an adjunct professor of psychiatry. Donald J. Trump gets re-elected president, and some people express regret, dismayed by what their vote really meant. Example: “My government contractor colleague voted for Trump and then found out after the election that he intends to fire federal contractors on day one.” The […]

‘My former work colleague gave me her kidney’

Source link : https://www.newshealth.biz/health-news/my-former-work-colleague-gave-me-her-kidney/ BBC Jamie Lonsdale was delighted when Lauren Lane answered his plea on Facebook A man who made a desperate online plea for a kidney donor is now recuperating from a successful transplant after a former work colleague answered the call. Jamie Lonsdale, 36, put the appeal out on Facebook and it […]

Dartitis: The condition where you try to throw a dart

Source link : https://www.newshealth.biz/health-news/dartitis-the-condition-where-you-try-to-throw-a-dart/ Getty Images Former darts champion Kevin Painter suffers from Dartitis Former professional darts champion Kevin Painter has thrown arrows almost every day for 40 years. Throughout his career he thrived under pressure, playing in the most prestigious competitions and taking home more than £900,000 in prize money. But earlier this year, […]

Substantial Variation Seen in Ileosigmoid Fistula Management in Crohn’s Disease

Source link : https://www.newshealth.biz/health-news/substantial-variation-seen-in-ileosigmoid-fistula-management-in-crohns-disease/ ORLANDO — A considerable amount of variability exists in surgical management of ileosigmoid fistulas in Crohn’s disease (CD), according to a recent meta-analysis. Findings from six studies revealed that emergency surgery rates ranged from 5.7% to 57% and diversion rates ranged from 11.9% to 57%, reported Imran Khan, MD, of the […]

Homing in on Anthracyclines’ High-Risk Niche in Early Breast Cancer

Source link : https://www.newshealth.biz/health-news/homing-in-on-anthracyclines-high-risk-niche-in-early-breast-cancer/ SAN ANTONIO — Women with larger, genomically high-risk breast cancers had significantly lower risk of distant metastasis with chemotherapy that included an anthracycline, a new analysis of a randomized trial showed. Patients with a 21-gene assay score ≥31 had a 68% reduction in the risk of distant metastasis at 5 years […]

Alpha-Gal May Drive Sensitivity to IV Stelara in People With Red-Meat Allergies

Source link : https://www.newshealth.biz/health-news/alpha-gal-may-drive-sensitivity-to-iv-stelara-in-people-with-red-meat-allergies/ ORLANDO — First-dose reactions to IV ustekinumab (Stelara) may be related to IgE recognition of a carbohydrate allergen in patients, who may be able to tolerate subcutaneous ustekinumab instead, according to a small study. The biologic seemed to express an epitope to alpha-1,3-galactose (alpha-gal) that IgE antibodies recognize in people with […]

What Was Jamie Foxx’s Mystery Ailment?

Source link : https://www.newshealth.biz/health-news/what-was-jamie-foxxs-mystery-ailment/ The 24-hour news cycle is just as important to medicine as it is to politics, finance, or sports. At MedPage Today, new information is posted daily, but keeping up can be a challenge. As an aid for our readers, and for a little amusement, here is a 10-question quiz based on […]

Medical Assistance in Dying; Health Benefits of Chocolate?

Source link : https://www.newshealth.biz/health-news/medical-assistance-in-dying-health-benefits-of-chocolate/ TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center in El Paso, look at the top medical stories of the week. This week’s topics include […]

How Cyberattacks Hold Patient Care Hostage

Source link : https://www.newshealth.biz/health-news/how-cyberattacks-hold-patient-care-hostage/ Patel is professor of health behavior and health equity. My 68-year-old mother called her doctor’s office for 8 days straight and never got a response. She needed her diabetes drug adjusted as well as an evaluation for eye surgery. She had to hold her diabetes medication close to her face to […]

Wound HealingToolbox Requires Frequent Updating

Source link : https://www.newshealth.biz/health-news/wound-healingtoolbox-requires-frequent-updating/ NEW YORK, NY — Instructions on wound healing often involve disturbing photographs of severe diabetic ulcers, angry autoimmune blistering, and oozing lesions produced by uncommon genetic disorders, but whether or not they are dramatic, day-to-day dermatologic wound care relies on both the basics as well as novel approaches, according to a […]

Texas Sues New York Doctor for Prescribing Abortion Pills to Dallas-Area Woman

Source link : https://www.newshealth.biz/health-news/texas-sues-new-york-doctor-for-prescribing-abortion-pills-to-dallas-area-woman/ Texas has sued a New York doctor for prescribing abortion pills to a woman near Dallas, launching one of the first challenges in the U.S. to shield laws that Democrat-controlled states passed to protect physicians after Roe v. Wade was overturned. Texas Attorney General Ken Paxton filed the lawsuit on Thursday […]

Pharmacists Can Address Gaps in Long-Acting PrEP Care for HIV

Source link : https://www.newshealth.biz/health-news/pharmacists-can-address-gaps-in-long-acting-prep-care-for-hiv/ NEW ORLEANS — A collaborative drug therapy management (CDTM) program introduced by pharmacists helped improve access to long-acting HIV prevention in at-risk individuals, a researcher reported here. In the EquiPrEP study, the addition of a CDTM pharmacist in a municipal hospital system decreased the time to prior authorization for long-acting pre-exposure […]

Turns Out That Biosimilars Do Impact Biologic Drug Costs

Source link : https://www.newshealth.biz/health-news/turns-out-that-biosimilars-do-impact-biologic-drug-costs/ Introduction of biosimilars for the rheumatology drug adalimumab, whose original branded version Humira has long been a blockbuster, appears to have led to a dramatic drop in net spending for these products — even though biosimilars barely dented Humira prescription rates. Analysis of prescriptions and sales figures for 2023 — the […]

FDA Revokes EUAs of Four COVID-19 Monoclonal Antibodies

Source link : https://www.newshealth.biz/health-news/fda-revokes-euas-of-four-covid-19-monoclonal-antibodies/ The FDA on Friday revoked the emergency use authorizations (EUAs) of four monoclonal antibodies for COVID-19. The four drugs — bebtelovimab, sotrovimab, casirivimab/imdevimab (REGN-COV2), and tixagevimab/cilgavimab (Evusheld) — had been authorized for COVID-19 as treatments or as pre- or post-exposure prophylaxis for individuals at high risk of severe outcomes. Casirivimab/imdevimab had […]

Sleep Apnea Patients Have Higher Rates of Age-Related Macular Degeneration

Source link : https://www.newshealth.biz/health-news/sleep-apnea-patients-have-higher-rates-of-age-related-macular-degeneration/ Obstructive sleep apnea (OSA) was linked to a more than twofold risk of developing age-related macular degeneration (AMD) in a retrospective cohort study. Among 58,700 matched pairs of patients with OSA and controls, a 5-year analysis found that the OSA group was more likely to develop nonexudative AMD (2.05% vs 0.76%; […]

Dementia Incidence Linked to Inflammatory Foods

Source link : https://www.newshealth.biz/health-news/dementia-incidence-linked-to-inflammatory-foods/ Diets higher in inflammatory foods were linked to increased dementia risk in older adults. Risks were higher for both all-cause dementia and Alzheimer’s dementia. The study tracked Dietary Inflammatory Index scores measured at three time points over 10 years. Diets higher in inflammatory foods were tied to an increased incidence of […]

Hair Growth After Cancer; ‘Global’ Early-Onset CRC; Retifanlimab Boosts OS in NSCLC

Source link : https://www.newshealth.biz/health-news/hair-growth-after-cancer-global-early-onset-crc-retifanlimab-boosts-os-in-nsclc/ Oral minoxidil promoted hair regrowth with no serious side effects in women who had hair loss related to breast cancer treatment. (NYU Langone Health, Journal of the American Academy of Dermatology) The FDA issued a second, expanded recall of duloxetine after higher than acceptable levels of a cancer-causing chemical were found […]

Better Quality of Life With RT vs Endocrine Therapy in Older Breast Cancer Patients

Source link : https://www.newshealth.biz/health-news/better-quality-of-life-with-rt-vs-endocrine-therapy-in-older-breast-cancer-patients/ SAN ANTONIO — Endocrine therapy after breast-conserving surgery was associated with worse health-related quality of life (HRQOL) compared with radiotherapy in older women with luminal A-like early breast cancer, interim results from the randomized EUROPA trial showed. At 24 months, endocrine therapy appeared to have a more negative effect on HRQOL […]

Extra-Musculoskeletal Manifestations in Axial Spondyloarthritis

Source link : https://www.newshealth.biz/health-news/extra-musculoskeletal-manifestations-in-axial-spondyloarthritis/ The chronic back pain of axial spondyloarthritis (axSpA) may be accompanied after diagnosis by three primary extra-musculoskeletal manifestations — uveitis, psoriasis, or inflammatory bowel disease (IBD). These manifestations can also precede a long delay in axSpA diagnosis. “Axial spondyloarthritis, an immune-mediated inflammatory disease, not only affects the axial and peripheral skeleton, […]

Nancy Pelosi Hospitalized | MedPage Today

Source link : https://www.newshealth.biz/health-news/nancy-pelosi-hospitalized-medpage-today/ Former House Speaker Nancy Pelosi has been hospitalized after she “sustained an injury” during an official engagement in Luxembourg, according to a spokesman. Pelosi, 84, was in Europe to mark the 80th anniversary of the Battle of the Bulge in World War II. Her spokesman, Ian Krager, said in a statement […]

FDA Advisors Say More Data Needed for RSV Vaccines in Young Kids

Source link : https://www.newshealth.biz/health-news/fda-advisors-say-more-data-needed-for-rsv-vaccines-in-young-kids/ FDA advisors said that more data are needed to fully understand if there are broader safety concerns related to use of respiratory syncytial virus (RSV) vaccines in young children after an mRNA vaccine trial was halted earlier this year. Moderna, which had been developing an mRNA vaccine candidate for RSV in […]

MedPod Today: CEO Murder Shows Industry Risks; RFK Jr. Conspiracies; Gold Card Laws

Source link : https://www.newshealth.biz/health-news/medpod-today-ceo-murder-shows-industry-risks-rfk-jr-conspiracies-gold-card-laws/ The following is a transcript of the podcast episode: Rachael Robertson: Hey everybody. Welcome to MedPod Today, the podcast series where MedPage Today reporters share deeper insight into the week’s biggest healthcare stories. I’m your host, Rachael Robertson. Today, we are talking with Michael DePeau-Wilson about how the murder of United […]

EMA Endorses Two ADHD Treatments for Children

Source link : https://www.newshealth.biz/health-news/ema-endorses-two-adhd-treatments-for-children/ Two treatments for children with attention-deficit hyperactivity disorder (ADHD) have been recommended by the European Medicines Agency (EMA) to receive marketing authorizations. Paxneury for ADHD Symptoms The agency’s Committee for Medicinal Products for Human Use (CHMP) said it was satisfied that Paxneury (guanfacine) reduces behavioral symptoms of ADHD such as hyperactivity, […]

Self-Replicating mRNA Vaccine for COVID Prevention

Source link : https://www.newshealth.biz/health-news/self-replicating-mrna-vaccine-for-covid-prevention/ Europe’s Committee for Medicinal Products for Human Use (CHMP) recommended granting marketing authorization for two drugs for preventing COVID-19: a monoclonal antibody called Kavigale (sipavibart) and a self-amplifying mRNA vaccine known as Kostaive (zapomeran). The recommendations are now in line for approval by the European Commission. The active ingredient in Kavigale […]

Rytelo Recommended in Europe for Myelodysplastic Syndromes

Source link : https://www.newshealth.biz/health-news/rytelo-recommended-in-europe-for-myelodysplastic-syndromes/ The European Medicines Agency (EMA) has given a positive recommendation for Rytelo (imetelstat) for the treatment of adult patients with transfusion-dependent anemia due to very low-, low-, or intermediate-risk myelodysplastic syndromes. Myelodysplastic syndromes are a group of cancers in which blood cells in the bone marrow do not mature, build up, […]

Back Trouble, Brain Fog Bothered Suspect in UnitedHealthcare CEO Killing, Posts Show

Source link : https://www.newshealth.biz/health-news/back-trouble-brain-fog-bothered-suspect-in-unitedhealthcare-ceo-killing-posts-show/ After Luigi Mangione made the difficult decision to undergo spinal surgery last year for chronic back pain, he became a proponent of the procedure that changed his life for the better. He repeatedly posted on Reddit about his recovery and offered words of encouragement for people with similar conditions, telling them […]

No Apparent Harm From Omitting Lymph Node Dissection in Selected Breast Cancers

Source link : https://www.newshealth.biz/health-news/no-apparent-harm-from-omitting-lymph-node-dissection-in-selected-breast-cancers/ SAN ANTONIO — Patients with early breast cancer who skipped axillary lymph node dissection (ALND) lived just as long as those who underwent sentinel lymph node biopsy (SLNB), the randomized INSEMA trial showed. The estimated 5-year invasive disease-free survival (IDFS) rate was 91.9% in patients who omitted ALND and 91.7% for […]

Europe Approves Its First Drug for Von Hippel-Lindau Tumors

Source link : https://www.newshealth.biz/health-news/europe-approves-its-first-drug-for-von-hippel-lindau-tumors/ The European Medicines Agency (EMA) has recommended that a new oral agent, Welireg (belzutifan), be granted conditional marketing authorization for treatment of two different diseases: the rare genetic disorder von Hippel-Lindau disease (VHL) and a type of advanced renal cell carcinoma often featuring the same gene fault. Welireg represents the first […]

Emcitate Recommended for Peripheral Thyrotoxicosis in AHDS

Source link : https://www.newshealth.biz/health-news/emcitate-recommended-for-peripheral-thyrotoxicosis-in-ahds/ The European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended granting marketing authorization for Emcitate (tiratricol) for treating peripheral thyrotoxicosis in patients with Allan-Herndon-Dudley syndrome (AHDS).  Emcitate was designated as an orphan medicinal product for treating AHDS in 2017. The Committee for Orphan Medicinal Products will […]

EMA Supports Expanding Use of Ofev to Pediatric ILDs

Source link : https://www.newshealth.biz/health-news/ema-supports-expanding-use-of-ofev-to-pediatric-ilds/ The European Medicines Agency (EMA) has recommended extending the use of Ofev (nintedanib) to include treating progressive fibrosing interstitial lung diseases (ILDs) in children and adolescents aged 6 years or older. Varying Ofev’s marketing authorization would mark the first approved therapy in Europe for these respiratory conditions in children. Fibrosing ILDs […]

RFK Jr.’s Lawyer Asks FDA to Pull Polio Vaccine; Pollution-VTE Link; H5N1 in Cats

Source link : https://www.newshealth.biz/health-news/rfk-jr-s-lawyer-asks-fda-to-pull-polio-vaccine-pollution-vte-link-h5n1-in-cats/ Note that some links may require registration or subscription. The lawyer helping Robert F. Kennedy Jr. pick health officials to serve in the upcoming Trump administration has petitioned the FDA to revoke approval of the polio vaccine. (New York Times) In other Trump administration news, Ed Martin, an activist who raised […]

Insurers Are Dictating Care and We’re Sick, Sick, Sick of It!

Source link : https://www.newshealth.biz/health-news/insurers-are-dictating-care-and-were-sick-sick-sick-of-it/ N. Adam Brown is a practicing emergency physician, entrepreneur, and healthcare executive. He is the founder of ABIG Health, a healthcare growth strategy firm, and a professor at the University of North Carolina’s Kenan-Flagler Business School. Follow The killing of UnitedHealthcare executive Brian Thompson sent shockwaves through the medical community, Wall […]

Mpox became a global health emergency for the second time in 2024

Source link : https://www.newshealth.biz/health-news/mpox-became-a-global-health-emergency-for-the-second-time-in-2024/ A Red Cross worker spraying chlorine-based disinfectant in Goma in the Democratic Republic of the Congo in August 2024 MOISE KASEREKA/EPA-EFE/Shutterstock Mpox surged in parts of East, West and Central Africa in 2024, prompting the World Health Organization (WHO) to declare it a public health emergency of international concern in August. […]

Eight healthy habits could slow the ageing of your brain

Source link : https://www.newshealth.biz/health-news/eight-healthy-habits-could-slow-the-ageing-of-your-brain/ Exercise has many health benefits Jane Williams/Alamy Getting a good night’s sleep and other healthy habits could slow the biological ageing of your brain, potentially protecting against conditions like dementia. These habits, known as the Life’s Essential 8 checklist, were originally intended to help people boost their cardiovascular health. They include […]

EMA Recommends Seladelpar for Primary Biliary Cholangitis

Source link : https://www.newshealth.biz/health-news/ema-recommends-seladelpar-for-primary-biliary-cholangitis/ The European Medicines Agency (EMA) has recommended granting marketing authorization for Seladelpar Gilead (seladelpar lysine dihydrate) to treat primary biliary cholangitis (PBC). PBC is a chronic autoimmune liver disease marked by inflammation and progressive destruction of the small bile ducts within the liver. This leads to the accumulation of toxic bile […]

‘Urgent Need’ to Examine Anti-Seizure Medication Pricing

Source link : https://www.newshealth.biz/health-news/urgent-need-to-examine-anti-seizure-medication-pricing/ LOS ANGELES — The median cost of brand-name anti-seizure medications (ASMs) in the United States almost doubled from 2013 to 2023, whereas generic ASM prices declined over the same period, results of a new study showed. These findings highlight an “urgent need” to examine ASM pricing, study investigator Pradeep Javarayee, MD, […]

Early Success Seen With CAR T-Cell Therapy for SSc

Source link : https://www.newshealth.biz/health-news/early-success-seen-with-car-t-cell-therapy-for-ssc/ TOPLINE: CD19-targeting chimeric antigen receptor (CAR) T-cell therapy shows potential to intercept fibrotic organ manifestations and improve disease measures in patients with diffuse cutaneous systemic sclerosis (SSc) who had disease progression despite multiple previous treatments. METHODOLOGY: Researchers conducted a case series to examine the effect of CD19-targeting CAR T-cell therapy on […]

Imlunestrant Shows PFS Benefit in Advanced Breast Cancer

Source link : https://www.newshealth.biz/health-news/imlunestrant-shows-pfs-benefit-in-advanced-breast-cancer/ SAN ANTONIO — Second-line treatment with imlunestrant improved progression-free survival compared with standard endocrine monotherapy in patients with advanced estrogen receptor (ER)–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancer who had ESR1 mutations, according to recent findings from the EMBER-3 trial. This progression-free survival benefit with imlunestrant did not […]

Oral Doxycycline Shows Promise in Ocular Syphilis Care

Source link : https://www.newshealth.biz/health-news/oral-doxycycline-shows-promise-in-ocular-syphilis-care/ TOPLINE: Oral doxycycline (200 mg twice daily for 28 days) appears to be as effective as intravenous (IV) penicillin for the treatment of ocular syphilis for some patients with the condition. METHODOLOGY: Researchers conducted a retrospective cohort study of ocular syphilis cases diagnosed from 2017 to 2023 in Los Angeles, analyzing […]

Tamoxifen Reduces Risk for Invasive Recurrence of DCIS

Source link : https://www.newshealth.biz/health-news/tamoxifen-reduces-risk-for-invasive-recurrence-of-dcis/ SAN ANTONIO — For patients with so-called “good-risk” ductal carcinoma in situ (DCIS) who did not have radiation therapy after breast-conserving surgery, adjuvant tamoxifen reduced their overall risks for invasive recurrence, but not their risks for recurrence in either the same or contralateral breast. These findings come from an exploratory analysis […]

Health Impacts of Micro- and Nanoplastics

Source link : https://www.newshealth.biz/health-news/health-impacts-of-micro-and-nanoplastics/ In preparation for a future international treaty aimed at reducing plastic pollution, the French Parliamentary Office for the Evaluation of Scientific and Technological Choices presented the conclusions of a public hearing on the impact of plastics on various aspects of human health. Increased Global Plastic Production Philippe Bolo, a member of […]

Indoor Tanning Not Tied to Melanoma Mutational Burden

Source link : https://www.newshealth.biz/health-news/indoor-tanning-not-tied-to-melanoma-mutational-burden/ TOPLINE: Indoor tanning exposure was not associated with tumor mutational burden (TMB) in patients with cutaneous melanoma, in a retrospective cohort study. Higher TMB was linked to older age, head and neck tumors, and a history of nonmelanoma skin cancer (NMSC). METHODOLOGY: Researchers conducted a retrospective cohort study at a tertiary […]

Rituximab and Abatacept May Contribute to Cancer Risk in RA

Source link : https://www.newshealth.biz/health-news/rituximab-and-abatacept-may-contribute-to-cancer-risk-in-ra/ TOPLINE: The initiation of biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), particularly rituximab and abatacept, is associated with an increased risk for incident cancer in patients with rheumatoid arthritis (RA) within 2 years of starting treatment. METHODOLOGY: The researchers conducted a retrospective cohort study to assess the safety of tumor […]

Kids’ Flu Vaccination Rates Continue to Plummet This Season

Source link : https://www.newshealth.biz/health-news/kids-flu-vaccination-rates-continue-to-plummet-this-season/ Dec. 12, 2024 — The big drop in child flu vaccination rates last year appears to not be a blip. Just 37% of kids have gotten flu shots this year, according to new CDC data. That’s down 7 percentage points, from 44% of kids getting shots by this same time last […]

Common Supplements May Lead Youth to Steroid Use

Source link : https://www.newshealth.biz/health-news/common-supplements-may-lead-youth-to-steroid-use/ TOPLINE: Muscle-building dietary supplement (MBS) use among young men substantially increases the odds of subsequent anabolic-androgenic steroid (AAS) initiation. Users of MBS showed elevated odds of incident AAS use within 1-5 years, supporting the gateway hypothesis for escalating risk-taking behaviors to increase muscularity. METHODOLOGY: Analysis included data from two Growing Up […]

Dexamethasone-Sparing Approach Helps Frail Older Adults

Source link : https://www.newshealth.biz/health-news/dexamethasone-sparing-approach-helps-frail-older-adults/ Treated with a dexamethasone-sparing regimen, frail older adult patients with newly diagnosed multiple myeloma (MM) show significant reductions in disease progression and improvements in quality of life, new research shows. The study “is the first randomized phase 3 study dedicated to frail patients,” said first author Salomon Manier, MD, PhD, an […]

Support for Omitting SLNB in Some Early Breast Cancers

Source link : https://www.newshealth.biz/health-news/support-for-omitting-slnb-in-some-early-breast-cancers/ SAN ANTONIO — Recent findings from the INSEMA trial provided more evidence that omitting axillary sentinel lymph node biopsy (SLNB) does not compromise survival in women with low-risk, early-stage invasive breast cancer undergoing breast-conserving surgery. Among patients with clinically node-negative, stage T1 or T2 invasive breast cancer, the 5-year invasive disease-free […]

A sense of belonging aids our recovery

Source link : https://www.newshealth.biz/health-news/a-sense-of-belonging-aids-our-recovery/ Richard Donaldson Richard Donaldson is recovering from treatment A man who has been fighting prostate cancer has described how group fitness sessions have helped recovery and offered a “sense of belonging”. Richard Donaldson, 55, is among a group of 16 men who have completed the varied health programme at Aberdeen FC’s […]

Psychologists and Psychotropic Rx: An Old Debate Heats Up

Source link : https://www.newshealth.biz/health-news/psychologists-and-psychotropic-rx-an-old-debate-heats-up/ Utah recently became the seventh state to allow trained psychologists to prescribe psychotropics, sparking hope among supporters but raising safety concerns from critics. Medscape Medical News Source link : https://www.medscape.com/viewarticle/psychologists-and-psychotropic-prescribing-old-debate-heats-2024a1000n2l?src=rss Author : Publish date : 2024-12-13 09:37:19 Copyright for syndicated content belongs to the linked Source. Author : News Health Publish […]

Feds Take Aim at Dry-Cleaning Chemicals, Red Dye No. 3

Source link : https://www.newshealth.biz/health-news/feds-take-aim-at-dry-cleaning-chemicals-red-dye-no-3/ Health concerns have prompted the Environmental Protection Agency to ban certain chemicals used for dry cleaning and for making everyday products like glue. One of the chemicals being banned is a solvent called trichloroethylene, which is often used to remove grease from metal, but also is used in adhesives, paint remover, […]

Abdominal Pain Common in Both Active and Quiescent UC

Source link : https://www.newshealth.biz/health-news/abdominal-pain-common-in-both-active-and-quiescent-uc/ TOPLINE:  Abdominal pain is prevalent in patients with active and quiescent ulcerative colitis (UC), affects a higher proportion of patients during active disease, and is worse among women, patients with anxiety, and those with active disease. METHODOLOGY: Researchers analyzed the data from three existing cohorts of adult patients with UC from […]

ARBs Cut Epilepsy Risk in Patients with Hypertension

Source link : https://www.newshealth.biz/health-news/arbs-cut-epilepsy-risk-in-patients-with-hypertension/ LOS ANGELES — Angiotensin receptor blockers (ARB) are more effective than other antihypertensive medications in reducing the risk for post-stroke epilepsy (PSE), new research showed. Investigators found ARBs are better at cutting the PSE risk in individuals with high blood pressure than angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers (CCBs), and […]

Orthostatic Rises in SBP Not Tied to Increased CVD

Source link : https://www.newshealth.biz/health-news/orthostatic-rises-in-sbp-not-tied-to-increased-cvd/ TOPLINE: Among middle-aged adults in the Atherosclerosis Risk in Communities (ARIC) study, standing hypertension (systolic blood pressure [SBP] ≥ 140 mm Hg when standing) is associated with an increased risk for cardiovascular disease (CVD), whereas orthostatic increases in SBP do not show a significant association. METHODOLOGY: Recent consensus statements recommend defining […]

E-Scooter, E-Bike Injuries Tripled in US Since 2019

Source link : https://www.newshealth.biz/health-news/e-scooter-e-bike-injuries-tripled-in-us-since-2019/ Emergency department visits due to e-scooter and e-bike injuries have tripled since 2019 in the United States, with roughly 10% of injuries influenced by alcohol and substance abuse, according to a new study published in Injury Prevention. Researchers analyzed emergency department visits from 2019 to 2022 using the National Electronic Injury […]

General Anesthesia for C-Sections: A Mental Health Risk?

Source link : https://www.newshealth.biz/health-news/general-anesthesia-for-c-sections-a-mental-health-risk/ TOPLINE: The use of general anesthesia during cesarean deliveries is associated with an increased risk for postpartum depression (PPD) that necessitates hospitalization as well as a risk for suicidality, regardless of obstetric complications. METHODOLOGY: Researchers conducted a retrospective cohort study to assess the association of the use of general anesthesia for […]

NT-proBNP May Predict Atrial Fibrillation Risk Early

Source link : https://www.newshealth.biz/health-news/nt-probnp-may-predict-atrial-fibrillation-risk-early/ TOPLINE: Elevated levels of N-terminal pro–B-type natriuretic peptide (NT-proBNP), a key biomarker for diagnosing heart failure, show a nearly fourfold increased risk for atrial fibrillation (AF) in at-risk individuals. The utility of this biomarker was particularly evident in older adults and when serum-based measurements were used. METHODOLOGY: Researchers conducted a meta-analysis […]

Who Leads Long-Term Breast Cancer Survivor Care?

Source link : https://www.newshealth.biz/health-news/who-leads-long-term-breast-cancer-survivor-care/ TOPLINE: Over half of breast cancer survivors (57.2%) report oncologist-led care more than 5 years posttreatment, while only 22.4% receive Primary Care Provider (PCP)-led care. Patient confidence in PCP ability to manage survivorship care is linked to increased PCP involvement. METHODOLOGY: There are currently 4.1 million breast cancer survivors in the […]

The condition that makes people hate fidgeting

Source link : https://www.newshealth.biz/health-news/the-condition-that-makes-people-hate-fidgeting/ Getty Images Hair twiddling can be distressing to watch if you have misokinesia “If I see someone tapping their fingers on a desk, my immediate thought is to chop their fingers off with a knife,” an anonymous patient confides to a researcher. Another shares: “When I see someone making really small […]

Experts Weigh Benefits of Drug Price Negotiation and Other Price-Curbing Strategies

Source link : https://www.newshealth.biz/health-news/experts-weigh-benefits-of-drug-price-negotiation-and-other-price-curbing-strategies/ Policy experts punched holes in drug companies’ claims that the Medicare Drug Price Negotiation Program will stunt innovation and weighed in on other drug price-curbing strategies during a webinar hosted by the National Institute for Health Care Management (NIHCM) Foundation on Wednesday. The Backlash to Medicare Drug Price Negotiation A number […]

Growing Price Tag Reported for Newer De Facto Stroke Lytic

Source link : https://www.newshealth.biz/health-news/growing-price-tag-reported-for-newer-de-facto-stroke-lytic/ NEW ORLEANS — Tenecteplase in recent years outpaced alteplase as the stroke thrombolytic of choice at one large hospital system, despite shrinking cost savings, a researcher reported here. In 2021, clinicians at Cardinal Health-managed and consulting hospitals used alteplase almost exclusively for acute ischemic stroke. But the tide turned to tenecteplase […]

Palbociclib Regimen Yields ‘Incredible’ PFS Gain in Metastatic Breast Cancer

Source link : https://www.newshealth.biz/health-news/palbociclib-regimen-yields-incredible-pfs-gain-in-metastatic-breast-cancer/ SAN ANTONIO — The addition of palbociclib (Ibrance) to current standard-of-care therapy following induction chemotherapy resulted in a significant and clinically meaningful improvement in progression-free survival (PFS) in patients with hormone receptor (HR)-positive, HER2-positive metastatic breast cancer, the phase III PATINA study showed. The median PFS was 44.3 months among patients […]

Lung Cancer Drug Osimertinib Tied to Cardiac Events, Even in Low-Risk Patients

Source link : https://www.newshealth.biz/health-news/lung-cancer-drug-osimertinib-tied-to-cardiac-events-even-in-low-risk-patients/ The non-small cell lung cancer (NSCLC) drug osimertinib (Tagrisso) was associated with an increased risk of therapy-related cardiovascular (CV) events compared with older EGFR inhibitors, a retrospective cohort study from Taiwan found. In a matched analysis of 401 patients with EGFR-mutant NSCLC, therapy-related CV events occurred in 14.9% of those who […]

MD Reacts to Anesthesia Policy; Debunking Pedialyte Misinfo; Passion vs Practicality

Source link : https://www.newshealth.biz/health-news/md-reacts-to-anesthesia-policy-debunking-pedialyte-misinfo-passion-vs-practicality/ The following contains links to social media websites including X, TikTok, Instagram, Facebook, and LinkedIn. “Babe, wake up, your surgery isn’t done yet but we can’t afford anymore anesthesia,” joked emergency physician Josh Trebach, MD, on Bluesky, commenting on Anthem Blue Cross Blue Shield’s now reversed policy to put time limits […]

Trump Nearly Backed 16-Week Federal Abortion Ban

Source link : https://www.newshealth.biz/health-news/trump-nearly-backed-16-week-federal-abortion-ban/ Donald Trump was on the verge of backing a 16-week federal abortion ban earlier this year when aides staged an intervention. According to Time magazine’s cover story on his selection as its 2024 Person of the Year, Trump’s aides first raised concerns in mid-March that the abortion cutoff being pushed by […]

MedPAC Members Supportive of Upping Medicare Pay Rates Close to the Inflation Rate

Source link : https://www.newshealth.biz/health-news/medpac-members-supportive-of-upping-medicare-pay-rates-close-to-the-inflation-rate/ Members of the Medicare Payment Advisory Commission (MedPAC) seemed favorable Thursday to a proposed recommendation to Congress that Medicare should pay physicians based on the rate of medical inflation and give primary care doctors who serve low-income beneficiaries an extra pay bump. “I think the chair’s recommendation is directionally correct,” said […]

Skip Surgery for DCIS in Favor of Active Monitoring?

Source link : https://www.newshealth.biz/health-news/skip-surgery-for-dcis-in-favor-of-active-monitoring/ SAN ANTONIO — Active monitoring for low-risk ductal carcinoma in situ (DCIS) did not lead to a higher rate of ipsilateral invasive cancer versus guideline-recommended treatment, the randomized COMET trial showed. The 2-year cumulative rate of invasive cancer in the same breast was 4.2% with active monitoring and 5.9% with standard-of-care […]

Risk-Reducing Surgery May Benefit BRCA Carriers With Early-Onset Breast Cancer

Source link : https://www.newshealth.biz/health-news/risk-reducing-surgery-may-benefit-brca-carriers-with-early-onset-breast-cancer/ SAN ANTONIO — Carriers of germline BRCA mutations diagnosed with breast cancer by age 40 who underwent risk-reducing surgeries had lower rates of mortality and breast cancer recurrence than those who did not undergo these surgeries, according to results from an international cohort study presented here. Among more than 5,000 patients […]

Jamie Foxx’s Stroke: Here’s What to Know

Source link : https://www.newshealth.biz/health-news/jamie-foxxs-stroke-heres-what-to-know/ Actor, comedian, and singer Jamie Foxx revealed that his mystery ailment last year was a brain bleed and stroke. In his new comedy special “Jamie Foxx: What Had Happened Was,” filmed in the fall in Atlanta and now streaming on Netflix, Foxx came on stage in high spirits, dancing and working […]

New Investigation Casts Doubt on Landmark Ticagrelor Trial

Source link : https://www.newshealth.biz/health-news/new-investigation-casts-doubt-on-landmark-ticagrelor-trial/ New questions about the landmark trial that launched the antiplatelet drug ticagrelor worldwide are being raised after an investigation uncovered more information about how the PLATO study was conducted. Peter Doshi, PhD, senior editor at The BMJ, obtained primary records for the trial and unpublished data through a Freedom of Information […]

The 7 Biggest Financial Enemies of Doctors

Source link : https://www.newshealth.biz/health-news/the-7-biggest-financial-enemies-of-doctors/ Success in personal finance and reaching financial freedom is not complicated. But that does not mean it is necessarily easy — especially for doctors. Healthcare professionals actually have some significant financial enemies working against us. These financial enemies do not excuse us from working on our financial well-being. Nor should they […]

Doc Confesses to Killing Wife, Police Say; Nurse Reprimanded for Cursing at Toddler

Source link : https://www.newshealth.biz/health-news/doc-confesses-to-killing-wife-police-say-nurse-reprimanded-for-cursing-at-toddler/ Orlando-area physician Thomas Wentzell, MD, was arrested and confessed to killing his wife, according to local police. (WFTV9) Twenty lawsuits were filed alleging sexual abuse of psychiatric patients at Four Winds hospitals in Lewisboro and Saratoga Springs, New York. (Rockland/Westchester Journal News) Johanna Olson-Kennedy, MD, who has served as medical director […]

FDA Issues Safety Alert on Liver Disease Drug

Source link : https://www.newshealth.biz/health-news/fda-issues-safety-alert-on-liver-disease-drug/ Postmarketing data on obeticholic acid (Ocaliva) identified a risk for serious liver injury in primary biliary cholangitis (PBC) patients without cirrhosis, the FDA said in a safety communication on Thursday. The agency’s review of a mandated clinical trial “found that some cases of liver injury in patients without cirrhosis resulted in […]

Subcutaneous Cancer Immunotherapies Provide New Options for Physicians and Patients

Source link : https://www.newshealth.biz/health-news/subcutaneous-cancer-immunotherapies-provide-new-options-for-physicians-and-patients/ One of the most meaningful shifts in the cancer treatment landscape has been the move toward therapies that not only fight the disease, but also empower patients and healthcare professionals (HCPs) with choices on how they receive and provide care. Subcutaneous (SC) cancer immunotherapies are at the forefront of this shift, […]

Pulled Myeloma Drug Improves Survival in Trial

Source link : https://www.newshealth.biz/health-news/pulled-myeloma-drug-improves-survival-in-trial/ SAN DIEGO — A significant overall survival (OS) benefit with belantamab mafodotin (belantamab; Blenrep) in a phase III trial of relapsed or refractory multiple myeloma should smooth the way for the drug’s reintroduction to the U.S. market. In the DREAMM-7 study, OS rates at 3 years improved from 60% with the […]

HER2 Low and Ultralow Designations Open Door to Expansion of ADCs in Breast Cancer

Source link : https://www.newshealth.biz/health-news/her2-low-and-ultralow-designations-open-door-to-expansion-of-adcs-in-breast-cancer/ The HER2-low and HER2-ultralow breast cancer subtype designations have led to a changed landscape in HER2-directed therapies, as well as a desire for more sensitive assays that may better quantify HER2 expression. The HER2-low subcategory has particular relevance, since more than 50% of breast cancers are defined as HER2-low. From Binary […]